Oxford Biodynamics to present four papers at Malaysian Endocrine and Metabolic Society Annual Congress

Dr Alexandre Akoulitchev, Chief Scientific Officer of Oxford BioDynamics, commented:

“Type 2 diabetes mellitus is a public health threat in Malaysia, associated with major health risk factors and of very high prevalence – over 20% among adults over 30 years of age. Many people are also affected by pre-diabetic conditions, which are often asymptomatic and cause a gradual negative impact on their health. OBD is using its EpiSwitch™ biomarker technology to develop prognostic stratifications for those with type 2 diabetes and in the pre-diabetic state. This can lead to early diagnosis, disease monitoring and profiling of these individuals and therefore has the potential to make an important contribution to this growing health concern not only in Malaysia, but more widely.”

Oxford Biodynamics Plc (LON:OBD), a biotechnology company focused on the discovery and development of epigenetic biomarkers based on regulatory genome architecture, for use within the pharmaceutical and biotechnology industry, today announced that it will present four papers at the 10th Malaysian Endocrine and Metabolic Society Annual Congress (“MAC10”) to be held from 19-21 July 2019 at the Hilton Kuala Lumpur Hotel, Malaysia. The papers will showcase potential EpiSwitch™ biomarker applications for type 2 diabetes mellitus (T2DM) and will be presented by team members from OBD’s reference laboratory in Penang, Malaysia, together with collaborators from Hospital Seberang Jaya, a prominent Malaysian government hospital.

The papers focus on the successful development and validation of powerful progressive biomarkers in T2DM and demonstrate how OBD’s EpiSwitch™ technology can assist experts in endocrinology in the management of T2DM and pre-diabetes, potentially reducing expenditure on treatment for a country which is severely affected by the disease. The data stems from an ongoing T2DM study with a cohort of Malaysian volunteers that OBD has been conducting since 2016. Collaborating with public and private hospitals including Hospital Seberang Jaya and Penang Adventist Hospital, the study has recruited more than 400 subjects and analysed more than 2,000 data points in the form of blood samples.

OBD will present on the following topics: “Identification of chromosome conformation signatures involved in progression of Type-2 Diabetes Mellitus using EpiSwitch™”; “Islet cell autoantibody profile in a Malaysian Type-2 Diabetes Mellitus population”; “Is Alzheimer’s disease risk factor apolipoprotein E polymorphism a risk factor of Type-2 Diabetes Mellitus?”; and, with colleagues from Hospital Seberang Jaya, “Comparison of diagnostic performance and clinical utility of different HbA1c criteria against oral glucose tolerance test (OGTT) in screen detection of diabetes in Penang, Malaysia”.

Click to view all articles for the EPIC:
Or click to view the full company profile:
    Facebook
    Twitter
    LinkedIn
    Oxford BioDynamics

    More articles like this

    Oxford BioDynamics

    How are EpiSwitch markers detected?

    Introduction: Getting the basics right Oxford BioDynamics’ (OBD) EpiSwitch™ biomarker discovery platform combined with their newly enhanced detection technology gives the company valuable quantitative insights into chromosome conformations (DNA protein complexes) that regulate normal and disease

    Oxford BioDynamics

    What is EpiSwitchTM and how is it used?

    Oxford BioDynamics’ EpiSwitch™ technology is based on epigenetics, mechanisms that alter gene expression without altering the underlying DNA sequence and whose deregulation plays a role in the development of cancer, autoimmune, and neurologic diseases. Although DNA

    Oxford BioDynamics

    Sanders-Brown research highlights form of severe dementia

    The long-running study on aging and brain health at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) Alzheimer’s Disease Center has once again resulted in important new findings – highlighting a complex and under-recognized form

    Oxford BioDynamics

    Researchers identify new genetic defect linked to ALS

    Mutations in the UBQLN2 gene, known to cause amyotrophic lateral sclerosis (ALS), promote the buildup of toxic waste in brain cells by preventing the normal function of two cellular degradation mechanisms, a study has found. In addition to its known role

    Oxford BioDynamics

    New questions about Covid-19

    The coronavirus is known with certainty that it emerged in China in November and has since spread to almost the entire world, where it has infected more than 5 million people and killed at least 356,000. Older adults are more

    Oxford BioDynamics

    EpiSwitch technology selected as biomarker platform for COVID-19

    Oxford BioDynamics’ EpiSwitch technology has been chosen as the biomarker platform for prognostic and predictive profiling of COVID-19 patients in the GETAFIX clinical study.Institute of Infection, Immunity and Inflammation, University of Glasgow, and NHS Scotland are

    Oxford BioDynamics

    Rare Diseases Clinical Research Network Opens Online Survey on COVID-19

    The Rare Diseases Clinical Research Network (RDCRN) has opened an online survey to better understand how the COVID-19 outbreak is affecting people with rare diseases, their families, and caregivers. Survey questions cover a patient’s physical and mental health, supply of treatments, and

    Oxford BioDynamics

    Pandemic moves ALS Awareness Month events and activities online

    ALS Awareness Month has been observed each May since 1992. But this year, the COVID-19 pandemic has forced supporters to rethink ways to raise funds and awareness for amyotrophic lateral sclerosis (ALS). In previous years, May has been full of fundraising and educational activities

    Oxford BioDynamics

    ALS Awareness

    “I think it’s time we stop, children, what’s that sound? Everybody look what’s going down.” That call for awareness comes from the song “For What It’s Worth” by Buffalo Springfield. The song’s writer, Stephen Stills, penned the lyrics in

    Oxford BioDynamics

    ALS Awareness Month This May

    Within weeks following my ALS diagnosis, I faced my first ALS Awareness Month. At the time, I was still figuring out exactly what I had and how to pronounce amyotrophic lateral sclerosis. Never mind trying to educate others about it. I hated

    Oxford BioDynamics

    Microarray Facility

    The purpose-built Oxford Biodynamics Array facility offers a complete sample processing service for Comparative Genome Hybridization (CGH) using the Agilent microarray platform.  Agilent’s flexible SurePrint technology produces high-quality arrays of 60-mer oligonucleotides in a range of

    Oxford BioDynamics

    EpiSwitch biomarker discovery platform

    INTRODUCTION • The EpiSwitch biomarker discovery platform detects systemic changes in the cellular genomic architecture using a microarray and PCR-based biomarker platform (Figure 1)1. It identifies and monitors chromosome conformation signatures (CCSs), key regulatory processes that