Graphene Ink that is Used in Roll to Roll Printing for Biomedical Applications

Introduction

The growing demand for cell-based assays to determine the interaction occurring between cells and chemical and biological materials or compounds has pushed the development of sensing systems and methodologies that are capable of providing continuous results in real time, at high throughput and at low cost. The combination of biological components, such as proteins, with electrically conductive interdigital structures, is a non-invasive methodology that has the potential to fulfill these requirements.

Sensors for biological applications with interdigital structures already exist today. In fact, various commercial variants that use electrically conductive structures composed of biocompatible metals, such as gold or platinum, are currently available and typically produced using photolithographic methods. Since cell-based sensors are used to examine viable cells, a biocompatible interface to a fluidic system is required, and can typically be accomplished through bonding the wells to the printed circuit board that comprises the electrically conductive interdigital structures. It is important to note that these structures are often expensive to produce as a result of the complex production method of the biocompatible interdigital structures.

Haydale’s Graphene-Containing Ink

Haydale has recently developed and tested the biocompatibility, cytotoxicity, conductivity and suitability of a new graphene-containing ink for gravure printing. The ink was successfully found to meet the requirements concerning printability and application in a cell-based sensor. With this novel ink, printed structures can be produced with a surface resistance of 10 Ω/sq based on a layer thickness of 25 μm. A newly developed micro-engraving machine with an ultra-short pulse laser was used to create the print cylinder that is capable of producing structures with lateral dimensions measuring less than 10 μm.

For sensor production, a compact roll-to-roll printing system for two-color printing has been set up with established printing parameters. Additionally, the system is equipped with an integrated corona unit for surface activation of the substrate and each of the two printing units are equipped with a near-infrared drying unit. The plant, graphene ink and the developed processes are all suitable for high speed printing of conductive graphene electrodes, which are designed as interdigital structures. Even very fine electrode structures with widths of 52 microns and a distance of 52 microns between the adjacent fingers can be printed with this technology.

This graphene-containing ink is nano-enhanced, electrically conductive and biocompatible as a printed layer. The biocompatibility of the ink was demonstrated in cytotoxicity tests according to ISO 10993-5 with different cell lines, which led to the modification of the ink to allow for its application through rotary gravure printing. To ensure the accuracy and definition of the printing technology at high speed, the ink needed to be formulated to have a suitable viscosity and rapid drying.

Click to view all articles for the EPIC:
Or click to view the full company profile:
    Facebook
    Twitter
    LinkedIn
    Haydale Graphene Industries Plc

    More articles like this

    Hardman & Co

    Haydale Graphene Industries Plc Enlightenment delayed

    Haydale Graphene Industries Plc (LON:HAYD), Financial issues are now likely to affect the shares in the near term, as the group seeks new working capital funding arrangements. However, commercial developments are generally progressing well, and the

    Haydale Graphene Industries Plc

    Haydale Graphene Industries PLC Interim Results

    Haydale Graphene Industries PLC (LON:HAYD), the global advanced materials group, today announced its unaudited interim results for the six months ended 31 December 2017 (the ‘Period’ or ‘H1FY18’).   Financial Highlights   ·        67% increase in total unaudited

    Haydale Graphene Industries Plc

    Graphene Talk: Haydale Graphene Industries PLC

    News and an insightful interview with Ray Gibbs, CEO of Haydale Graphene Industries plc (LON:HAYD). Get a unique perspective on how the graphene industry is developing today.   Graphene Talk is a production of The Graphene

    Haydale Graphene Industries Plc

    Haydale Graphene Industries PLC Trading Update

    Haydale Graphene Industries PLC (LON:HAYD), the global advanced materials group, has today provided the following update on trading for the six months ended 31 December 2017 (the ‘Period’) as well as the prospects for the Group.

    Haydale Graphene Industries Plc

    Haydale Graphene Industries PLC Change of Adviser

    Haydale Graphene Industries PLC (LON:HAYD), the global advanced materials group, has today announced the appointment of Arden Partners plc as nominated adviser to the Group with immediate effect.   Haydale Graphene Industries is a United Kingdom-based company,

    Haydale Graphene Industries Plc

    Mapping The Graphene Environment

    Haydale Graphene Industries PLC (LON:HAYD) CEO Ray Gibbs features in an ITN production for the Graphene Council.   Haydale Graphene Industries is a global technologies and advanced materials group that facilitates the integration of nanomaterials into the

    Haydale Graphene Industries Plc

    Haydale Graphene Files for Anti-counterfeiting Technology Patent

    Carmarthenshire-based Haydale Graphene Industries PLC (LON:HAYD) has filed a UK patent application for its anti-counterfeiting technology. The company’s PATit technology uses proprietary software codes and a speciality graphene-based transparent conductive ink. This enables counterfeiting devices to

    Haydale Graphene Industries Plc

    Haydale Graphene Industries PLC New Patent Application

    Haydale Graphene Industries plc (LON:HAYD), the global advanced materials group, has today announced the filing of a patent application in the UK for its PATit anti-counterfeiting technology utilising proprietary software codes and a speciality graphene-based transparent conductive

    Haydale Graphene Industries Plc

    2D Materials – A quest for clean water

    Our quest to help make seawater drinkable leads to a scientific discovery we weren’t expecting – salt ions that can change shape Desalination of seawater remains one of the most challenging and expensive ways to produce

    Haydale Graphene Industries Plc

    Directors buy into Haydale Graphene Industries plc fundraising

    Haydale Graphene Industries plc LON:HAYD announced this morning that, following completion of the recent placing, subscription and offer for subscription, it has received notifications of dealings in restricted securities from certain PDMRs. The Directors’ interests following completion