4D pharma plc publication of data highlighting ability of MRx0004

4D pharma plc (LON: DDDD), a pharmaceutical company leading the development of live biotherapeutics, today announced the publication of a paper demonstrating that MRx0004, a live biotherapeutic derived from the human gut microbiome, can protect against airway inflammation by reducing both neutrophilic and eosinophilic infiltration in a mouse model of severe asthma.

The paper “Bifidobacterium breve MRx0004 protects against airway inflammation in a severe asthma model by suppressing both neutrophil and eosinophil lung infiltration” (Raftis et al.) is published in the Nature Publishing Group journal Scientific Reports.

Asthma is a phenotypically heterogeneous disease. Between 5 and 10 % of asthma patients have a severe form of the disease which is refractory to steroid treatment and whose symptoms cannot be controlled despite the application of high-intensity treatments. In severe asthma, airway inflammation can be predominantly eosinophilic, neutrophilic, or mixed and patients presenting with neutrophilic inflammation have particularly poor treatment options. Severe asthma is estimated to account for more than 60 % of asthma-associated healthcare costs.

MRx0004 is a strain of Bifidobacterium breve isolated from the gut microbiome of a healthy human. It was tested prophylactically and therapeutically in a house dust mite mouse model of severe asthma. A strong reduction of neutrophil and eosinophil infiltration was observed in lung bronchoalveolar lavage fluid (BALF) following MRx0004 treatment. Furthermore, MRx0004 had a striking effect on lung histopathology, with a strong reduction of both peribronchiolar and perivascular inflammatory infiltrate. The efficacy of MRx0004 exceeded that of the anti-IL-17 positive control used in the experiment.

Dr. Alex Stevenson, 4D’s Chief Scientific Officer, commented: “This data provides further evidence that live biotherapeutics have the potential to change the way we treat disease. Using MRx0004, we have demonstrated superior efficacy to biologics in a severe and steroid-resistant model of asthma.”

He added: “Perhaps more significantly, we have shown that MRx0004 can strongly reduce neutrophil and eosinophil airway infiltration concurrently. This is something which is not achievable with current therapies and is further evidence of the potential of MRx0004 as a next-generation therapeutic for the management of asthma.”

Click to view all articles for the EPIC:
Or click to view the full company profile:
    Facebook
    Twitter
    LinkedIn
    4d Pharma Plc

    More articles like this

    4d Pharma Plc

    People with fibromyalgia have different gut bacteria

    A study that compared women with and without fibromyalgia has, for the first time, linked gut bacteria to the long-lasting disease and its main symptoms. Researchers in Canada identified 19 species of gut bacteria that were

    4d Pharma Plc

    Findings link gut bacteria and Fibromyalgia

    Fibromyalgia affects 2-4 percent of the population and has no known cure. Symptoms include fatigue, impaired sleep, and cognitive difficulties, but the disease is most clearly characterized by widespread chronic pain. As reported in the journal Pain,

    4d Pharma Plc

    Gut bacteria: The surprising impact of viruses

    The microbiome plays a vital role in health. A recent study has investigated how viruses that kill gut bacteria influence these microbes. The findings make an already complicated picture much more so. The microbiome is both

    4d Pharma Plc

    4D pharma plc Presents MRx0518 combination study at ASCO

    4D pharma plc (LON: DDDD), a pharmaceutical company leading the development of Live Biotherapeutics, today announced the presentation of a poster detailing its Phase I/II clinical study of MRx0518 combined with KEYTRUDA® in patients with solid

    4d Pharma Plc

    4D pharma plc Directors purchase more shares in company

    4D pharma plc (LON: DDDD), a pharmaceutical company leading the development of Live Biotherapeutics, has today announced that David Norwood, Duncan Peyton and Alex Stevenson have purchased ordinary shares in the Company as listed below. Following this transaction,

    4d Pharma Plc

    4D pharma plc Presents Phase Ib Clinical Data on Thetanix

    4D pharma plc (LON: DDDD), a pharmaceutical company focusing on the development of Live Biotherapeutics, today announced that data from the completed Phase Ib clinical study of Thetanix® for the treatment of Crohn’s disease will be

    4d Pharma Plc

    Can this food additive turn our gut bacteria against us?

    E171 is a food additive that manufacturers use to whiten various products, including chewing gum, cake icing, and candy, for instance. While the addition of this substance may render certain products more appealing, there is an

    4d Pharma Plc

    7 Things Doctors Want You To Know About IBS

    Irritable bowel syndrome, or IBS, is one of those health conditions that can be difficult to talk about. And when you are struggling with things like diarrhea, constipation, gas, and bloating, it’s completely understandable. But there

    4d Pharma Plc

    4D pharma plc Participation in Microbiome Conference

    4D pharma plc (AIM: DDDD), a pharmaceutical company leading the development of Live Biotherapeutics, today announces its participation in the inaugural Chardan Capital Markets LLC Microbiome Medicines Summit. Alex Stevenson, 4D’s Chief Scientific Officer, gave a